Description

H-D-Ala-Pro-Phe-Oh is a synthetic tripeptide derivative of significant interest in pharmaceutical research and development. This compound serves as a crucial building block and a model substrate for studying enzyme specificity and peptide stability. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents and diagnostic tools. The material is valued for its defined structure, which facilitates investigations into metabolic pathways and drug delivery mechanisms.

Application

• Pharmaceutical Intermediate: Used in the research and synthesis of novel peptide-based drugs and prodrugs.
• Biochemical Research: Acts as a standard or substrate in enzymatic studies, particularly for proteases and peptidases.
• Medicinal Chemistry: Serves as a key scaffold for structure-activity relationship (SAR) studies to optimize pharmacological properties.
• Academic Research: Employed in universities and laboratories for teaching and fundamental research in peptide chemistry and biochemistry.
• Diagnostic Development: Potential use in the development of assay kits and biomarkers for clinical diagnostics.

Basic Information

Product Name	H-D-Ala-Pro-Phe-Oh
CAS No.	105931-66-6
Molecular Formula	C₁₇H₂₂N₄O₄
Molecular Weight	346.38 g/mol
Synonyms	H-D-Ala-L-Pro-L-Phe-OH; D-Alanyl-L-prolyl-L-phenylalanine; (2R)-2-[[(2S)-1-[(2S)-2-Amino-1-oxo-3-phenylpropyl]pyrrolidin-2-yl]formamido]propanoic acid; D-Ala-Pro-Phe; Ala-Pro-Phe peptide derivative; Tripeptide inhibitor substrate; APF peptide
EINECS	Contact for details

Quality Control

Our H-D-Ala-Pro-Phe-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic identification (NMR, MS). A Certificate of Analysis (COA) detailing the specific results for identity, assay, and impurities is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	95.0% - 105.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.