Description

H-Val-Pro-Oh Hcl CAS NO 105931-64-4 is a high-purity, protected dipeptide building block used extensively in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over peptide chain assembly, particularly for complex or therapeutic sequences. It serves as an essential raw material for pharmaceutical R&D, the production of active pharmaceutical ingredients (APIs), and biochemical research applications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of therapeutic peptides and peptidomimetics.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected valyl-proline unit for the controlled elongation of peptide chains.
• Biochemical Research: Employed in studying enzyme-substrate interactions, protease specificity, and peptide structure-activity relationships (SAR).
• API Development: Serves as a critical intermediate in the development and scale-up of novel peptide-based Active Pharmaceutical Ingredients.
• Combinatorial Chemistry: Utilized in libraries for drug discovery to generate diverse peptide analogs for screening.

Basic Information

Product Name	H-Val-Pro-Oh Hcl
CAS No.	105931-64-4
Molecular Formula	C10H19N2O3 • HCl
Molecular Weight	250.73 g/mol (Free base: 215.27 g/mol)
Synonyms	L-Valyl-L-proline; Val-Pro-OH • HCl; H-Val-Pro-OH hydrochloride; N-(N-Valyl)proline hydrochloride; Boc-Val-Pro-OH (precursor); V-P Dipeptide HCl; Z-Val-Pro-OH (related derivative); Fmoc-Val-Pro-OH (related derivative)
EINECS	Contact for details

Quality Control

Our H-Val-Pro-Oh Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: -60° to -70° (c=1 in H₂O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.