Description

Prothrombin Precursor (13-29) CAS NO 105931-25-7 is a defined synthetic peptide fragment corresponding to a specific sequence of the prothrombin protein. This high-purity biochemical is critical for advanced research and development in the fields of hemostasis and thrombosis. It serves as an essential reference standard and active ingredient for scientists and manufacturers in the pharmaceutical, diagnostic, and life science sectors, enabling precise study and manipulation of blood coagulation pathways.

Application

• Biochemical Research: Used as a key substrate or inhibitor in enzymatic studies to investigate the mechanisms of blood coagulation, particularly thrombin generation and activity.
• Diagnostic Reagent Development: Serves as a critical component in the formulation of in vitro diagnostic (IVD) kits for assessing prothrombin time (PT), activated partial thromboplastin time (aPTT), and other coagulation factor assays.
• Pharmaceutical R&D: Employed in the discovery and screening of novel anticoagulant and procoagulant therapeutics targeting specific sites on the prothrombin molecule.
• Quality Control Standard: Acts as a certified reference material (CRM) for the calibration and validation of analytical methods in quality control laboratories.
• Peptide Synthesis & Conjugation: Provides a well-characterized peptide backbone for further chemical modification, conjugation with labels, or structure-activity relationship (SAR) studies.

Basic Information

Product Name	Prothrombin Precursor (13-29)
CAS No.	105931-25-7
Molecular Formula	C73H122N24O23S2
Molecular Weight	1687.0 g/mol
Synonyms	Prothrombin Fragment 1 Residues 13-29; Human Prothrombin (13-29); Thrombin Precursor Peptide (13-29); FPR-13-29; H-Arg-Tyr-Leu-Pro-Arg-Ser-Pro-Gln-Asn-Val-Arg-Val-Glu-Gly-Ser-Glu-Cys-OH (Disulfide bridge: Cys18-Cys23); Prethrombin-2 related peptide; Coagulation Factor II Precursor (13-29)
EINECS	Contact for details

Quality Control

Our Prothrombin Precursor (13-29) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide comprehensive Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues, ensuring compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Amino Acid Composition	Within ±10% of theoretical values
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.