Description

Leucine, 4,5-Dihydroxy- (9Ci) is a specialized derivative of the essential amino acid leucine, characterized by the addition of hydroxyl groups at the 4 and 5 positions. This structural modification makes it a valuable chiral building block and intermediate in advanced organic synthesis and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for drugs targeting metabolic and neurological pathways.
• Biochemical Research: Used as a substrate or standard in enzymatic studies and metabolic pathway analysis to investigate leucine metabolism and its derivatives.
• Peptide Synthesis: Employed in the solid-phase and solution-phase synthesis of modified peptides, where the dihydroxy leucine moiety can influence peptide conformation and bioactivity.
• Agrochemical Development: Acts as a precursor in the synthesis of specialized amino acid-based herbicides or plant growth regulators.
• Fine Chemical Production: Utilized as a building block for synthesizing complex natural product analogs and other high-value specialty chemicals.

Basic Information

Product Name	Leucine, 4,5-Dihydroxy- (9Ci)
CAS No.	105817-05-8
Molecular Formula	C6H13NO4
Molecular Weight	163.17 g/mol
Synonyms	4,5-Dihydroxy-L-leucine; (2S,4S,5S)-4,5-Dihydroxyleucine; allo-4,5-Dihydroxyleucine; 4,5-Dihydroxy-2-aminohexanoic acid; 2-Amino-4,5-dihydroxyhexanoic acid; Dihydroxyleucine; L-4,5-Dihydroxyleucine
EINECS	Contact for details

Quality Control

Our Leucine, 4,5-Dihydroxy- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.