Description

D-Norleucine, 2-Methyl- (9Ci) is a non-proteinogenic amino acid derivative, specifically the D-isomer of 2-methylnorleucine. This chiral building block is valued for its role in advanced pharmaceutical research and peptide synthesis, where stereochemical purity is critical. It is primarily utilized by researchers and manufacturers in the life sciences sector for developing novel therapeutic peptides, enzyme inhibitors, and as a standard in analytical chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based drugs and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a non-natural, hydrophobic amino acid residue, altering peptide properties.
• Biochemical Research: Serves as a standard or reference compound in metabolic studies and for investigating amino acid transport and incorporation mechanisms.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in the synthesis of complex chiral molecules for medicinal chemistry.
• Proteomics & Diagnostics: Can be used in the design of specialized probes, substrates, or affinity tags for proteomic analysis and diagnostic assays.

Basic Information

Product Name	D-Norleucine, 2-Methyl- (9Ci)
CAS No.	105815-95-0
Molecular Formula	C7H15NO2
Molecular Weight	145.20 g/mol
Synonyms	D-2-Methylnorleucine; (R)-2-Amino-2-methylhexanoic acid; D-2-Amino-2-methylcaproic acid; (R)-2-Methylnorleucine; D-α-Methylnorleucine; D-2-Methyl-2-aminohexanoic acid; (R)-2-Methyl-2-aminohexanoic acid; D-Homoleucine (ambiguous, verify context)
EINECS	Contact for details

Quality Control

Our D-Norleucine, 2-Methyl- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing specific results for assay, enantiomeric excess, and related substances are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (D-isomer)
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.