Description

Temafloxacin Hydrochloride is a synthetic fluoroquinolone antibiotic compound, specifically the hydrochloride salt form of temafloxacin. Its primary value lies in its potent antibacterial activity against a broad spectrum of Gram-positive and Gram-negative organisms, making it a critical intermediate in pharmaceutical research and development. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly those focused on developing and studying advanced antibacterial agents, novel drug formulations, and conducting microbiological assays.

Application

• Pharmaceutical Intermediate: Serves as a key active pharmaceutical ingredient (API) or precursor in the synthesis of antibacterial medications.
• Antibacterial Research: Used in microbiological and pharmacological studies to investigate mechanisms of action, resistance patterns, and efficacy against various bacterial strains.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or other chromatographic methods to identify and quantify temafloxacin.
• Formulation Development: Utilized in pre-formulation and formulation studies for developing injectable, oral, or topical dosage forms.
• Biochemical Studies: Applied in research targeting DNA gyrase and topoisomerase IV enzymes to understand quinolone-class antibiotic interactions.

Basic Information

Product Name	Temafloxacin Hydrochloride
CAS No.	105784-61-0
Molecular Formula	C21H19F3N3O3 • HCl
Molecular Weight	477.85 g/mol (for free base: 441.39 g/mol)
Synonyms	Temafloxacin HCl; 1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride; (±)-1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride; Temafloxacin monohydrochloride; PD-117596-10; Abbott-56620
EINECS	Contact for details

Quality Control

Our Temafloxacin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting high-grade standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, impurity profile, and residual solvents. We support compliance with relevant pharmaceutical guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.