Description

Fmoc-Ser(Tbu)-Opfp is a specialized, protected amino acid derivative used as a key building block in solid-phase peptide synthesis (SPPS). This compound is critical for ensuring high coupling efficiency and maintaining the integrity of the serine side chain during the assembly of complex peptides. It is an essential reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester (Opfp), it serves as a highly reactive building block for the efficient incorporation of O-tert-butyl-protected serine into growing peptide chains.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormones, antibiotics, and enzyme inhibitors.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive molecules.
• Bioconjugation: Employed in the site-specific modification of peptides and proteins for creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Academic & Institutional Research: Fundamental reagent for studying peptide structure, function, and folding in biochemistry and molecular biology laboratories.
• Custom Peptide Service Providers: A standard raw material for CROs and CDMOs offering bespoke peptide synthesis services to the global market.

Basic Information

Product Name	Fmoc-Ser(Tbu)-Opfp
CAS No.	105751-13-1
Molecular Formula	C26H22F5NO6
Molecular Weight	539.45 g/mol
Synonyms	Fmoc-Ser(O-t-Bu)-OPfp; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-L-serine pentafluorophenyl ester; Fmoc-O-tert-butyl-L-serine pentafluorophenyl ester; Fmoc-L-Serine(O-t-butyl)-OPfp ester; Fmoc-Ser(tBu)-OPfp; Fmoc-Ser(OtBu)-OPfp; Pentafluorophenyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-L-serinate; Nα-Fmoc-O-tert-butyl-L-serine pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Ser(Tbu)-Opfp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material suitable for research and GMP-guided development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.