Description

γ-Glutamyl-Glutathione is a specialized tripeptide derivative of glutathione, featuring an additional γ-glutamyl moiety. This compound is of significant interest in biochemical research and pharmaceutical development due to its role as a potential precursor or intermediate in glutathione metabolism and redox signaling pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and manufacturers of high-purity biochemical reagents for studies in oxidative stress, enzymology, and metabolic processes.

Application

• Biochemical Research: Used as a critical substrate or standard in enzymatic studies, particularly those involving γ-glutamyl transpeptidase (GGT) and glutathione metabolism.
• Pharmaceutical R&D: Serves as a key intermediate or reference compound in the development of therapeutics targeting oxidative stress-related diseases, such as neurodegenerative disorders and liver conditions.
• Diagnostic Reagent Manufacturing: Employed in the formulation of assay kits and diagnostic reagents designed to measure glutathione-related enzyme activities or metabolite levels.
• Cell Culture & Neuroscience Studies: Applied in *in vitro* models to investigate the protective effects of glutathione derivatives against oxidative damage in neuronal and other cell types.
• Reference Standard: Provides a high-purity calibrant for analytical methods (HPLC, LC-MS) used in quantifying glutathione and its metabolites in biological samples.
• Nutritional Science Research: Investigated for its potential bioactivity and role in the body's antioxidant defense network, relevant for nutraceutical development.

Basic Information

Product Name	γ-Glutamyl-Glutathione
CAS No.	105644-04-0
Molecular Formula	C15H24N4O10S
Molecular Weight	452.44 g/mol
Synonyms	γ-Glu-GSH; L-γ-Glutamyl-L-glutathione; NSC 334156; Glutathione, L-γ-glutamyl-; (2S)-2-Amino-4-{[(1S)-1-[(carboxymethyl)carbamoyl]-2-[(2R)-2-[(carboxymethyl)amino]-3-sulfanylpropanamido]ethyl]carbamoyl}butanoic acid; γ-Glutamylglutathione; GSH dimer (γ-linked)
EINECS	Contact for details

Quality Control

Our γ-Glutamyl-Glutathione is produced under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment, identity confirmation by spectroscopic methods (IR, NMR), and tests for residual solvents and moisture. We are committed to meeting the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.