Description

α-(4-Fluorophenyl)-4-(5-Fluoro-2-Pyrimidinyl)-1-Piperazine Butanol is a high-purity, advanced pharmaceutical intermediate characterized by its specific piperazine and fluorinated aromatic structure. This compound is critical for the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and scale-up of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antipsychotic and neuroleptic drug candidates.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Serves as a critical precursor in the scale-up and commercial manufacturing of target APIs.
• Reference Standard: Employed as an analytical standard for quality control and method validation in API production.
• Biochemical Research: Tool compound for investigating receptor binding affinity and pharmacological profiles.

Basic Information

Product Name	α-(4-Fluorophenyl)-4-(5-Fluoro-2-Pyrimidinyl)-1-Piperazine Butanol
CAS No.	105565-56-8
Molecular Formula	C18H20F2N4O
Molecular Weight	346.37 g/mol
Synonyms	1-(4-Fluorophenyl)-4-[4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl]-1-butanol; 4-(4-(5-Fluoropyrimidin-2-yl)piperazin-1-yl)-α-(4-fluorophenyl)-1-butanol; BMS 181100; BMS-181100; UNII-9J97361D4I; 9J97361D4I; α-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol
EINECS	Contact for details

Quality Control

Our α-(4-Fluorophenyl)-4-(5-Fluoro-2-Pyrimidinyl)-1-Piperazine Butanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with client specifications and current industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.