Description

Cholecystokinin (26-33), n-Acetyl-Norleucine(28,31)- is a synthetic, biologically active peptide fragment derived from the gastrointestinal hormone cholecystokinin. This modified analog is engineered for enhanced stability and specificity in research applications, making it a critical tool for studying receptor interactions and signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neurogastroenterology, metabolic disorders, and peptide-based drug discovery.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies targeting CCK receptors (CCKA and CCKB subtypes) to understand their role in satiety, anxiety, and pain modulation.
• Biochemical Assay Development: Serves as a key ligand in receptor binding assays, competitive inhibition studies, and functional cellular assays to screen for novel therapeutics.
• Neuroscience Studies: Applied in research investigating the gut-brain axis, particularly the effects of cholecystokinin on neurotransmitter release and neuronal excitability.
• Drug Discovery & Preclinical Testing: Utilized in the design and evaluation of new peptide analogs and small molecules for treating gastrointestinal disorders, obesity, and pancreatic diseases.
• Academic & Institutional Research: Essential for basic science investigations into hormone action, peptide structure-activity relationships (SAR), and signal transduction mechanisms.

Basic Information

Product Name	Cholecystokinin (26-33), n-Acetyl-Norleucine(28,31)-
CAS No.	105504-60-7
Molecular Formula	C46H68N12O13S2
Molecular Weight	1021.2 g/mol
Synonyms	CCK-8 (desulfated analog); [Nle28,31]-CCK(26-33); Cholecystokinin Octapeptide, n-Acetyl-[Nle28,31]-; Ac-CCK-8; H-Asp-Tyr(SO3H)-Nle-Gly-Trp-Nle-Asp-Phe-NH2 (modified); CCK (26-33) fragment, acetylated norleucine analog; Suc-CCK-8 (Nle28,31); 105504-60-7
EINECS	Contact for details

Quality Control

Our Cholecystokinin (26-33), n-Acetyl-Norleucine(28,31)- is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with research-grade standards. Custom synthesis and purification to specific purity levels (>95%, >98%, >99%) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80% (by weight)
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.