Description

Cholecystokinin (26-33), n-α-Hydroxysulfonyl-Nle(28,31)- is a synthetic, sulfonated peptide fragment of the gastrointestinal hormone cholecystokinin. This modified analog is engineered for enhanced stability and specificity in research applications, particularly in receptor binding studies. It is a critical reagent for pharmaceutical R&D, academic research, and diagnostic development focused on the central nervous system and digestive functions.

Application

• Neuroscience Research: Used as a selective ligand for studying CCK receptor subtypes (CCKA and CCKB) in the brain, aiding in the investigation of anxiety, satiety, and pain modulation.
• Pharmacological Assay Development: Serves as a reference standard in high-throughput screening (HTS) for drug discovery programs targeting CCK receptors.
• Biochemical Tool: Employed in competitive binding assays, receptor autoradiography, and signal transduction studies to understand G-protein coupled receptor (GPCR) mechanisms.
• Diagnostic Reagent Manufacturing: Acts as a key component in the development of in vitro diagnostic (IVD) kits and immunoassays for gastrointestinal research.
• Academic & Institutional Research: Provides a stable, well-characterized peptide for fundamental studies in endocrinology and peptide hormone action.

Basic Information

Product Name	Cholecystokinin (26-33), n-α-Hydroxysulfonyl-Nle(28,31)-
CAS No.	105483-63-4
Molecular Formula	C46H68N10O16S2
Molecular Weight	1081.22 g/mol
Synonyms	CCK-8 (sulfated), sulfated; Cholecystokinin fragment 26-33 amide, sulfated; CCK-8S; Sincalide (sulfated analog); H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 (modified); [Nle28,31]-CCK(26-33) sulfonyl derivative; CCK octapeptide, sulfated form; n-α-Hydroxysulfonyl-Norleucine(28,31) Cholecystokinin (26-33)
EINECS	Contact for details

Quality Control

Every batch of our Cholecystokinin (26-33), n-α-Hydroxysulfonyl-Nle(28,31)- is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our quality system is designed to meet the exacting requirements of research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.