Description

(Nle8,21,Tyr34)-Pth (1-34) Amide (Rat) is a synthetic, biologically active peptide analog of rat parathyroid hormone. This compound is a critical research tool for studying calcium and phosphate metabolism, bone physiology, and endocrine signaling pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in metabolic disease research and drug discovery.

Application

• Endocrine Research: Investigation of parathyroid hormone (PTH) receptor binding, activation, and downstream signaling cascades.
• Metabolic Studies: Research into calcium homeostasis, bone remodeling, and renal phosphate handling.
• Drug Discovery & Development: Serving as a reference standard, positive control, or lead compound in the development of novel therapeutics for osteoporosis and hyperparathyroidism.
• Biochemical Assays: Use in in vitro and cell-based assays to evaluate PTH analog potency and efficacy.
• Academic & Preclinical Research: Fundamental studies in physiology and pharmacology to understand PTH structure-activity relationships.

Basic Information

Product Name	(Nle8,21,Tyr34)-Pth (1-34) Amide (Rat)
CAS No.	105267-88-7
Molecular Formula	C181H291N55O51
Molecular Weight	~4107.6 g/mol
Synonyms	Parathyroid Hormone (1-34) (Rat) Amide, [Nle8,21, Tyr34]-PTH(1-34)-NH2 (Rat); [Nle8,Nle21,Tyr34]-PTH(1-34) Amide (Rat); PTH (1-34) (Rat) Amide Analog; Rat PTH(1-34) Amide Fragment; Norleucine8,21, Tyrosine34 Parathyroid Hormone (1-34) Amide (Rat)
EINECS	Contact for details

Quality Control

Every batch of (Nle8,21,Tyr34)-Pth (1-34) Amide (Rat) is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure identity, purity, and biological activity, supporting reproducible research outcomes. A Certificate of Analysis (COA) detailing purity (by HPLC), peptide content, amino acid analysis, and mass spectrometry (MS) confirmation is supplied with each product.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass confirmed
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.