Description

2-Chloro-5-Fluoro-3-(Trifluoromethyl)Aniline is a high-purity, multi-functional aromatic amine building block of significant commercial importance. Its unique structure, featuring chloro, fluoro, and trifluoromethyl substituents, makes it a critical intermediate for synthesizing advanced molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Dye and Pigment Intermediate: Employed in the synthesis of complex, high-performance dyes and pigments for specialized industrial applications.
• Cross-Coupling Reactions: An essential substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination, Suzuki coupling) for creating complex biaryl structures.

Basic Information

Product Name	2-Chloro-5-Fluoro-3-(Trifluoromethyl)Aniline
CAS No.	105172-78-9
Molecular Formula	C7H4ClF4N
Molecular Weight	213.56 g/mol
Synonyms	2-Chloro-5-fluoro-3-(trifluoromethyl)benzenamine; 3-Amino-2-chloro-5-fluorobenzotrifluoride; 2-Chloro-5-fluoro-alpha,alpha,α-trifluoro-m-toluidine; 2-Chloro-5-fluoro-3-trifluoromethylaniline; Benzenamine, 2-chloro-5-fluoro-3-(trifluoromethyl)-; 2-Chloro-5-fluoro-3-(trifluoromethyl)phenylamine; 2-Chloro-5-fluoro-3-(trifluoromethyl)aniline (primary name)
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-3-(Trifluoromethyl)Aniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.