Description

H-2,5-Diiodo-His-Oh Hcl is a chemically modified derivative of the amino acid histidine, specifically diiodinated at the 2 and 5 positions of the imidazole ring. This modification is critical for research into enzyme inhibition, receptor binding studies, and the development of novel peptide-based pharmaceuticals. It serves as a valuable building block and research chemical for scientists in medicinal chemistry and biochemistry. Target users include pharmaceutical R&D teams, biotechnology companies, and academic institutions focused on peptide synthesis and metabolic pathway analysis.

Application

• Pharmaceutical Intermediate: Used in the research and synthesis of novel peptide drugs and enzyme inhibitors.
• Biochemical Research: Serves as a key reagent in studying histidine-related metabolic pathways and enzyme mechanisms.
• Medicinal Chemistry: Employed as a building block for creating analogs to explore structure-activity relationships (SAR).
• Proteomics & Peptide Synthesis: Utilized in solid-phase and solution-phase peptide synthesis for incorporating modified histidine residues.
• Radioligand Precursor: Acts as a precursor compound for the development of iodinated tracers used in imaging studies.
• Academic & Institutional Research: Fundamental research tool in university and institutional labs for biochemical studies.

Basic Information

Item	Detail
Product Name	H-2,5-Diiodo-His-Oh Hcl
CAS No.	105158-70-1
Molecular Formula	C6H9I2N3O2 • HCl
Molecular Weight	Contact for details
Synonyms	2,5-Diiodo-L-histidine hydrochloride; L-Histidine, 2,5-diiodo-, hydrochloride; Diiodohistidine HCl; H-Diiodo-His-OH • HCl; (2S)-2-Amino-3-(2,5-diiodo-1H-imidazol-4-yl)propanoic acid hydrochloride; 2,5-Diiodohistidine monohydrochloride; Research Grade Diiodohistidine HCl
EINECS	Contact for details

Quality Control

Our H-2,5-Diiodo-His-Oh Hcl is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR. We ensure compliance with relevant standards for research chemicals. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.