Description

Ethyl7-(3-Amino-1-Pyrrolidinyl)-6-Fluoro-1-(2,4-Difluorophenyl)-1,4-Dihydro-4-Oxo-1,8-Naphthyridine-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the naphthyridine class of compounds. This compound is of significant commercial importance as a key synthetic precursor in the development of novel antibacterial agents, particularly fluoroquinolone derivatives. It is primarily required by research institutions, contract development and manufacturing organizations (CDMOs), and active pharmaceutical ingredient (API) manufacturers engaged in the synthesis of next-generation antibiotics.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potent antibacterial fluoroquinolone drugs.
• Antibacterial Research: Used in medicinal chemistry research to develop new antibiotic candidates with improved efficacy and spectrum of activity.
• Process Development: Serves as a standard reference material for scaling up and optimizing API manufacturing processes.
• Chemical Synthesis: Employed in organic synthesis for constructing complex naphthyridine-based molecular frameworks.
• Analytical Standard: Utilized as a high-purity standard for quality control and analytical method development in pharmaceutical labs.

Basic Information

Product Name	Ethyl7-(3-Amino-1-Pyrrolidinyl)-6-Fluoro-1-(2,4-Difluorophenyl)-1,4-Dihydro-4-Oxo-1,8-Naphthyridine-3-Carboxylate
CAS No.	105152-95-2
Molecular Formula	C22H20F3N4O3
Molecular Weight	445.42 g/mol
Synonyms	Ethyl 7-(3-Aminopyrrolidin-1-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate; 1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester; 105152-95-2; 7-(3-Aminopyrrolidin-1-yl)-6-fluoro-1-(2,4-difluorophenyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid ethyl ester; A key intermediate for ABT-719; ABT-719 Intermediate
EINECS	Contact for details

Quality Control

Our Ethyl7-(3-Amino-1-Pyrrolidinyl)-6-Fluoro-1-(2,4-Difluorophenyl)-1,4-Dihydro-4-Oxo-1,8-Naphthyridine-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines suitable for pharmaceutical intermediate applications, ensuring reliable supply and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area. Due to its light-sensitive nature, prolonged exposure to direct light should be avoided.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.