Description

6,8-Difluoro-1-(2-Fluoroethyl)-7-(4-Methyl-1-Piperazinyl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, offering a critical structural motif for enhancing antimicrobial potency and spectrum. It is primarily required by pharmaceutical R&D laboratories, process development chemists, and manufacturers engaged in the synthesis of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of advanced fluoroquinolone antibiotic candidates.
• Antimicrobial Research: Used in medicinal chemistry programs to develop new antibacterial agents with improved activity against resistant strains.
• Process Chemistry: Serves as a key intermediate in scale-up and optimization studies for API (Active Pharmaceutical Ingredient) manufacturing.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development and quality control in pharmaceutical production.
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) of quinolone derivatives.

Basic Information

Product Name	6,8-Difluoro-1-(2-Fluoroethyl)-7-(4-Methyl-1-Piperazinyl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	105078-26-0
Molecular Formula	C19H22F3N3O3
Molecular Weight	397.39 g/mol
Synonyms	Ethyl 6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate; 1-(2-Fluoroethyl)-6,8-difluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic Acid Ethyl Ester; 6,8-Difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic Acid Ethyl Ester; PD 161148; PD-161148; A Fluoroquinolone Intermediate; Quinolone Derivative
EINECS	Contact for details

Quality Control

Our 6,8-Difluoro-1-(2-Fluoroethyl)-7-(4-Methyl-1-Piperazinyl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and identity, meeting the stringent requirements for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.