Description

Fmoc-Lys-Oh CAS NO 105047-45-8 is a protected amino acid derivative, specifically the Fmoc (9-fluorenylmethoxycarbonyl) derivative of L-lysine with a free carboxylic acid group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary building block for the controlled incorporation of lysine residues into custom peptide sequences.
• Pharmaceutical Research: Synthesis of peptide-based drug candidates, including hormones, antimicrobial peptides, and targeted therapeutics.
• Bioconjugation: Utilized to introduce reactive amine handles (after Fmoc deprotection) for linking peptides to other molecules, surfaces, or carriers.
• Combinatorial Chemistry: A key reagent in libraries for high-throughput screening of bioactive peptide compounds.
• Biochemical Tool Development: Production of substrates, inhibitors, and standards for enzymatic assays and proteomics research.
• Antibody-Drug Conjugate (ADC) Development: Used in synthesizing peptide linkers that connect cytotoxic drugs to antibodies.

Basic Information

Product Name	Fmoc-Lys-Oh
CAS No.	105047-45-8
Molecular Formula	C22H26N2O4
Molecular Weight	382.46 g/mol
Synonyms	Fmoc-L-lysine; Nα-Fmoc-L-lysine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-aminohexanoic acid; Fmoc-Lys-OH; Nα-(9-Fluorenylmethyloxycarbonyl)-L-lysine; Fmoc-Lysine; Fmoc-Lys; Nα-Fmoc-L-lysine-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Lys-Oh is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. A Certificate of Analysis (COA) detailing specific results for identity, assay, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storage at 2-8°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-10.0° to -12.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.