Description

5-Oxo-L-Pro-5-(Trifluoromethyl)-L-His-L-Pro-Nh2 is a specialized, high-purity synthetic peptide derivative designed for advanced research and development. This compound is valued for its unique trifluoromethylated histidine residue, which imparts distinct chemical and metabolic properties critical for pharmaceutical and biochemical applications. It serves as a key intermediate or reference standard for scientists in medicinal chemistry, peptide synthesis, and proteomics research, enabling the development of novel therapeutics and diagnostic tools.

Application

• Medicinal Chemistry & Drug Discovery: As a building block for synthesizing novel peptide-based drug candidates, particularly those targeting enzyme inhibition or requiring enhanced metabolic stability.
• Biochemical Research: Used as a reference standard or probe in studies of enzyme-substrate interactions, protein folding, and post-translational modifications due to its unique fluorinated side chain.
• Proteomics & Peptide Synthesis: A crucial intermediate in solid-phase or solution-phase peptide synthesis for creating custom peptides with specific functionalization.
• Pharmaceutical Development: Serves as a key raw material in the R&D phase for developing new active pharmaceutical ingredients (APIs) with improved pharmacokinetic profiles.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic chemistry, bioorganic chemistry, and chemical biology.

Basic Information

Product Name	5-Oxo-L-Pro-5-(Trifluoromethyl)-L-His-L-Pro-Nh2
CAS No.	104987-37-3
Molecular Formula	C17H22F3N5O4
Molecular Weight	417.38 g/mol
Synonyms	5-Oxo-L-prolyl-5-(trifluoromethyl)-L-histidyl-L-prolinamide; (S)-2-((S)-5-Oxo-1-(2-((S)-2-((S)-5-oxopyrrolidine-2-carbonyl)amino)-3-(5-(trifluoromethyl)-1H-imidazol-4-yl)propanamido)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxamide; 5-Oxo-Pro-5-CF3-His-Pro-NH2; L-Proline, 5-oxo-, 1-[(1S)-1-[[(2S)-1-amino-1-oxo-2-pyrrolidinyl]carbonyl]-2-[5-(trifluoromethyl)-1H-imidazol-4-yl]ethyl] ester; Trifluoromethyl Histidine Peptide Derivative; 5-Oxo-Proline-5-Trifluoromethyl-Histidine-Proline Amide
EINECS	Contact for details

Quality Control

Our 5-Oxo-L-Pro-5-(Trifluoromethyl)-L-His-L-Pro-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Chiral Purity	≥ 99.0% ee

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.