Description

Neuromedin K, Cyclic Cys(2,5) is a synthetic, cyclic peptide analog of the mammalian tachykinin neuropeptide. This compound is a potent and selective agonist for the neurokinin-3 (NK-3) receptor, making it a critical research tool for studying neuroendocrine signaling pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, endocrinology, and drug discovery programs.

Application

• Neuroscience Research: As a selective NK-3 receptor agonist for studying receptor function, signal transduction, and the role of tachykinins in the central and peripheral nervous systems.
• Endocrinology Studies: Investigation of neuroendocrine regulation, including the control of hormone secretion (e.g., LH, prolactin) and reproductive functions.
• Drug Discovery & Development: Serving as a reference standard, pharmacological tool, or lead compound in the development of novel therapeutics targeting NK-3 receptors for conditions like schizophrenia, depression, and metabolic disorders.
• In Vitro & In Vivo Assays: Used in cell-based functional assays (e.g., calcium flux, IP accumulation) and animal models to validate targets and assess compound efficacy.
• Biochemical Research: Study of peptide-receptor interactions, structure-activity relationships (SAR), and the design of more stable or potent peptide analogs.

Basic Information

Product Name	Neuromedin K, Cyclic Cys(2,5)
CAS No.	104953-10-8
Molecular Formula	C59H83N15O13S2
Molecular Weight	1250.51 g/mol
Synonyms	Cyclic Neuromedin K; Cyclic Cys(2,5)-Neuromedin K; [Cys2,5]-Neuromedin K; Neurokinin B (cyclic analog); NK-3 Receptor Agonist; Tachykinin Peptide Analog; Senktide (cyclic variant); Asp-His-Cys-Phe-Cys-Pro-Leu-Cys-NH2 (cyclic 2-5); H-Asp-His-Cys-Phe-Cys-Pro-Leu-Cys-NH2 (2-5 disulfide bridge)
EINECS	Contact for details

Quality Control

Our Neuromedin K, Cyclic Cys(2,5) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.