Description

1-(6-Chloro-9H-Purin-9-Yl)-1-Deoxy-2,3-o-Isopropylidene-β-D-Ribofuranuronoyl Chloride is a high-purity, protected nucleoside derivative that serves as a critical synthetic intermediate in modern organic chemistry. Its value lies in enabling the precise construction of complex molecules, particularly in the development of novel pharmaceuticals and bioactive compounds. This advanced building block is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for nucleoside analog synthesis and oligonucleotide chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used in the preparation of modified oligonucleotides for research, diagnostics, and therapeutic applications.
• Prodrug Development: Serves as a building block for creating prodrugs of nucleoside analogs to enhance bioavailability and targeting.
• Bioconjugation Chemistry: Facilitates the site-specific modification of biomolecules for labeling and drug delivery systems.
• Chemical Biology Research: Enables the study of nucleic acid interactions and enzyme mechanisms through the incorporation of modified bases.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Item	Details
Product Name	1-(6-Chloro-9H-Purin-9-Yl)-1-Deoxy-2,3-o-Isopropylidene-β-D-Ribofuranuronoyl Chloride
CAS No.	104940-65-0
Molecular Formula	C14H14Cl2N4O4
Molecular Weight	373.19 g/mol
Synonyms	6-Chloro-9-(2,3-O-isopropylidene-5-O-(chloroformyl)-β-D-ribofuranosyl)purine; 6-Chloropurine-9-(2',3'-O-isopropylidene-5'-O-chloroformyl-β-D-ribofuranoside); 1-(6-Chloro-9H-purin-9-yl)-1-deoxy-2,3-O-isopropylidene-β-D-ribofuranuronoyl chloride; 6-Chloro-9-(2,3-O-isopropylidene-5-O-chloroformyl-β-D-ribofuranosyl)purine; 6-Chloro-9-(2,3-O-isopropylidene-5-O-chloroformyl-β-D-ribofuranosyl)purine; 6-Chloro-9-(2,3-O-isopropylidene-5-O-chloroformyl-β-D-ribofuranosyl)-9H-purine; 6-Chloro-9-(2,3-O-isopropylidene-5-O-chloroformyl-β-D-ribofuranosyl)adenine precursor
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development and commercial projects requiring material that meets exacting research and cGMP-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.