Description

Dynorphin A (1-13), Ala(2)-Trp(4)- is a synthetic peptide fragment derived from the endogenous opioid peptide Dynorphin A. This modified sequence is a critical research tool for investigating the kappa opioid receptor (KOR) system and its role in pain modulation, addiction, and neurological disorders. It is primarily utilized by pharmaceutical researchers, neuroscientists, and biochemical suppliers engaged in advanced neuropharmacology and peptide-based drug discovery.

Application

• Neuroscience Research: As a selective ligand for studying kappa opioid receptor (KOR) signaling pathways, neuronal excitability, and synaptic plasticity.
• Pain Mechanism Studies: Investigation of endogenous opioid systems involved in stress-induced analgesia and chronic pain states.
• Psychopharmacology: Research into the role of dynorphin in reward circuitry, addiction behaviors, and mood disorders like depression.
• Biochemical Assay Development: Used as a reference standard or competing ligand in receptor binding assays (RBA) and radioimmunoassays (RIA).
• Peptide Drug Discovery: Serves as a lead compound or structural template for developing novel analgesics with reduced side-effect profiles.
• Academic & Institutional Research: Fundamental studies in universities and research institutes focusing on neuropeptide function and metabolism.

Basic Information

Product Name	Dynorphin A (1-13), Ala(2)-Trp(4)-
CAS No.	104746-05-6
Molecular Formula	C78H111N19O17
Molecular Weight	1554.85 g/mol
Synonyms	Dynorphin A (1-13) amide, [Ala2, Trp4]-; [Ala2,Trp4]-Dynorphin A (1-13); Dynorphin A 1-13 (Ala2, Trp4); H-Tyr-Ala-Phe-Trp-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-NH2; [Ala2, Trp4]-Dynorphin A (1-13) amide; Dynorphin A (1-13) (Ala2, Trp4) amide
EINECS	Contact for details

Quality Control

Our Dynorphin A (1-13), Ala(2)-Trp(4)- is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure high purity and sequence integrity, meeting the exacting standards required for biomedical research. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and peptide content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical composition
Mass Spectrometry (MS)	Consistent with theoretical molecular weight
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.