Description

5-Amino-2-(Trifluoromethoxy)Benzotrifluoride is a high-value, multi-fluorinated aromatic amine building block, essential for the synthesis of advanced materials and active pharmaceutical ingredients (APIs). Its unique structure, featuring both trifluoromethyl and trifluoromethoxy substituents, imparts significant lipophilicity, metabolic stability, and electronic properties to target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used to develop advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a key building block for fluorine-containing components in electronic display and lighting technologies.
• Polymer & Resin Modifier: Incorporated into specialty polymers to improve chemical resistance, thermal stability, and surface properties.
• Dye & Pigment Intermediate: Employed in the production of high-performance, light-fast fluorinated dyes and pigments.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Buchwald-Hartwig amination) to introduce the valuable 2-(trifluoromethoxy)aniline moiety into complex molecules.

Basic Information

Product Name	5-Amino-2-(Trifluoromethoxy)Benzotrifluoride
CAS No.	104678-68-4
Molecular Formula	C8H5F6NO
Molecular Weight	245.12 g/mol
Synonyms	2-Amino-α,α,α,1-tetrafluoro-6-(trifluoromethoxy)benzene; 2-(Trifluoromethoxy)-5-(trifluoromethyl)aniline; 5-Amino-2-(trifluoromethoxy)benzotrifluoride; 2-Trifluoromethoxy-5-trifluoromethylaniline; 5-(Trifluoromethyl)-2-(trifluoromethoxy)aniline; 2-(Trifluoromethoxy)-α,α,α,5-tetrafluorotoluidine; 1-Amino-4-(trifluoromethyl)-2-(trifluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our 5-Amino-2-(Trifluoromethoxy)Benzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent oxidation and absorption of water vapor. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Individual Unknown Impurity	≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.