Description

(R)-Pramipexole CAS NO 104632-28-2 is the single enantiomer form of the non-ergoline dopamine agonist pramipexole, characterized by its high purity and specific stereochemistry. This compound is of critical importance in advanced pharmaceutical research and development, particularly for creating enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of novel therapeutics for central nervous system disorders.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a key chiral intermediate or the final active moiety in the production of enantiomerically pure dopamine agonist medications.
• Neurological Disorder Research: Used in preclinical and clinical research targeting conditions such as Parkinson's disease and Restless Legs Syndrome (RLS).
• Pharmacological Studies: Employed in receptor binding assays and studies of D2-type dopamine receptor family activity to understand selectivity and efficacy.
• Chiral Reference Standard: Acts as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Formulation Development: Utilized in the development of various dosage forms, including immediate and extended-release tablets.
• Process Chemistry & Scale-Up: Provides a defined starting material for optimizing synthetic routes and scaling up production under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Item	Details
Product Name	(R)-Pramipexole
CAS No.	104632-28-2
Molecular Formula	C10H17N3S
Molecular Weight	211.33 g/mol
Synonyms	(R)-Pramipexole; (6R)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine; (R)-(-)-Pramipexole; Pramipexole R-isomer; SND 919CL2Y; (6R)-N6-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine; Mirapex Impurity F (R-isomer)
EINECS	Contact for details

Quality Control

Our (R)-Pramipexole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to relevant ICH guidelines and can supply material suitable for use under cGMP conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Individual impurity: ≤0.5% Total impurities: ≤1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.