Description

L-4-Cyanophenylalanine is a non-natural, side-chain-modified aromatic amino acid derivative that serves as a critical building block in advanced chemical synthesis. Its unique structure, featuring a cyano group on the phenyl ring, makes it an invaluable tool for probing protein structure and function, as well as for creating novel peptide-based materials. This high-purity biochemical is essential for researchers and manufacturers in pharmaceutical development, proteomics research, and specialty peptide synthesis, where precise molecular engineering is required.

Application

• Biophysical & Structural Biology: Used as a site-specific infrared or fluorescent probe in proteins via genetic codon expansion techniques.
• Pharmaceutical Research: Serves as a key intermediate in the development of novel peptide therapeutics and enzyme inhibitors.
• Chemical Biology Tool Development: Incorporated into peptides to study protein-protein interactions, folding, and stability.
• Material Science: A building block for synthesizing specialized polymers and biomaterials with unique electronic or structural properties.
• Academic & Industrial R&D: Employed in mechanistic studies and as a standard in analytical method development for amino acid analysis.

Basic Information

Product Name	L-4-Cyanophenylalanine
CAS No.	104531-20-6
Molecular Formula	C₁₀H₁₀N₂O₂
Molecular Weight	190.20 g/mol
Synonyms	L-p-Cyanophenylalanine; (S)-2-Amino-3-(4-cyanophenyl)propanoic acid; 4-Cyano-L-phenylalanine; L-4-CN-Phe; Fmoc-L-4-cyanophenylalanine (precursor); 4-Cyanophenylalanine, L-; L-β-(4-Cyanophenyl)alanine; PARA-CYANO-L-PHENYLALANINE
EINECS	Contact for details

Quality Control

Our L-4-Cyanophenylalanine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR, and MS for structural confirmation. We provide Certificates of Analysis (COA) with detailed batch-specific data to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.