Description

Substance P (5-11), Asparaginyl(5,6)-Methylphenylalanine(8)- CAS NO 104499-97-0 is a specific bioactive fragment of the neuropeptide Substance P, designed for targeted research and development applications. This compound is critical for studying the structure-activity relationships of Substance P and its interaction with neurokinin receptors, particularly the NK1 subtype. It is primarily utilized by pharmaceutical researchers, neuroscientists, and biochemical manufacturers focused on developing novel therapeutics for pain, inflammation, and central nervous system disorders.

Application

• Neuroscience Research: A key tool for investigating the role of Substance P in pain transmission, neurogenic inflammation, and neuronal signaling pathways.
• Drug Discovery & Development: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of NK1 receptor antagonists and other neuropeptide-targeted therapies.
• Biochemical Assays: Serves as a critical reagent in receptor binding studies, functional cell-based assays, and enzyme-linked immunosorbent assays (ELISAs) to quantify biological activity.
• Academic & Pharmaceutical R&D: Supports fundamental research in universities and industrial labs exploring the therapeutic potential of peptide fragments in various disease models.
• Peptide Synthesis & Custom Manufacturing: Acts as a building block or template for the synthesis of longer, modified peptide sequences with enhanced stability or specificity.

Basic Information

Product Name	Substance P (5-11), Asparaginyl(5,6)-Methylphenylalanine(8)-
CAS No.	104499-97-0
Molecular Formula	C41H59N11O9S
Molecular Weight	882.06 g/mol
Synonyms	Substance P (5-11) fragment; [pGlu5,MePhe8,Sar9]-Substance P (5-11); [pGlu5, N-Me-Phe8, Sar9]-Substance P (5-11); pGlu-Phe-Phe-N-Me-Phe-Gly-Leu-Met-NH2; Neurokinin receptor ligand fragment; NK1 receptor peptide agonist fragment; SP (5-11) analog
EINECS	Contact for details

Quality Control

Our Substance P (5-11) fragment is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. For cGMP-grade material or specific pharmacopeial standards (e.g., USP reference standards), please contact our technical sales team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Peptide Content	≥ 80.0% (by AAA)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.