Description

4-Bromo-2-Chloro-5-(Trifluoromethyl)Benzenamine is a high-purity, multi-functional halogenated aniline derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of bromo, chloro, and trifluoromethyl substituents on the aromatic ring, enabling precise molecular modifications and the introduction of key functional groups. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral drugs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and cross-coupling reactions (e.g., Buchwald-Hartwig amination).
• Material Science Research: Employed in the synthesis of advanced polymers, liquid crystals, and organic electronic materials due to its halogenated aromatic structure.
• Dye and Pigment Intermediate: Functions as a core component in the production of complex, high-performance dyes and pigments.
• Custom Synthesis and R&D: A versatile scaffold for medicinal chemistry and process research in contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	4-Bromo-2-Chloro-5-(Trifluoromethyl)Benzenamine
CAS No.	104460-69-7
Molecular Formula	C7H4BrClF3N
Molecular Weight	274.47 g/mol
Synonyms	2-Chloro-4-bromo-5-(trifluoromethyl)aniline; 5-Amino-2-bromo-4-chlorobenzotrifluoride; 4-Bromo-2-chloro-α,α,α-trifluoro-m-toluidine; 2-Bromo-4-chloro-5-aminobenzotrifluoride; Benzenamine, 4-bromo-2-chloro-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-4-bromo-2-chloroaniline; 2-Chloro-4-bromo-α,α,α-trifluoro-m-toluidine
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Chloro-5-(Trifluoromethyl)Benzenamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.