Description

3-Quinolinecarboxylic Acid, 8-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[3-[(Methylamino)Methyl]-1-Pyrrolidinyl]-4-Oxo- is a high-purity, complex heterocyclic compound serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a key building block for the synthesis of novel fluoroquinolone antibiotics, enabling the development of next-generation antimicrobial agents. This product is essential for research institutions and pharmaceutical manufacturers engaged in API development, targeting applications in human and veterinary medicine.

Application

• Pharmaceutical Intermediate: Primary use as a core synthon in the production of advanced fluoroquinolone antibiotic Active Pharmaceutical Ingredients (APIs).
• Antibacterial Drug Research: A vital precursor in R&D for novel antibacterial compounds with improved efficacy and spectrum of activity.
• Veterinary Medicine Synthesis: Used in formulating antimicrobial treatments for veterinary applications.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale manufacturing for new drug candidates.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in pharmaceutical labs.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 8-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[3-[(Methylamino)Methyl]-1-Pyrrolidinyl]-4-Oxo-
CAS No.	104455-87-0
Molecular Formula	C19H21ClFN3O3
Molecular Weight	393.84 g/mol
Synonyms	8-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-7-[3-[(methylamino)methyl]-1-pyrrolidinyl]-4-oxo-3-quinolinecarboxylic acid; Gatifloxacin Intermediate; AM-1155 Intermediate; (±)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methylaminopiperidin-1-yl)-4-oxoquinoline-3-carboxylic acid intermediate; 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylaminopiperidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid related compound; Gatifloxacin carboxylic acid derivative; 7-(3-Aminomethyl-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided and can be tailored to meet specific customer or regulatory standards (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.