Description

Histatin-5 is a naturally occurring antimicrobial peptide found in human saliva, known for its potent antifungal and antibacterial properties. Its primary value lies in its ability to disrupt microbial cell membranes and inhibit biofilm formation, making it a compound of significant interest for advanced research and development. This peptide is essential for researchers and formulators in the pharmaceutical, biotechnology, and oral care industries, particularly for studies in antimicrobial agents, wound healing, and dental hygiene products. The product is supplied under the identifier CAS NO 104339-66-4.

Application

• Antimicrobial Research: Fundamental studies on its mechanism of action against Candida albicans and other pathogenic fungi and bacteria.
• Oral Care Product Development: Investigation as a bioactive ingredient in mouthwashes, toothpastes, and chewing gums for caries prevention and periodontal health.
• Wound Healing Formulations: Exploration in topical creams, gels, and dressings to leverage its antimicrobial and potential tissue-regenerative properties.
• Biomaterial Coatings: Research into surface modifications for medical devices (e.g., catheters, implants) to prevent microbial colonization and biofilm formation.
• Biochemical & Structure-Activity Relationship (SAR) Studies: Used as a reference standard or lead compound for designing novel peptide-based therapeutics.
• Diagnostic Reagent Development: Potential use in assays and kits for studying host defense peptides and innate immunity.

Basic Information

Product Name	Histatin-5
CAS No.	104339-66-4
Molecular Formula	C152H238N56O51
Molecular Weight	3036.8 g/mol
Synonyms	Histatin 5; Histatin-5 (human); Salivary Histatin 5; Hst5; Antimicrobial Peptide Histatin-5; DSHAKRHHGYKRKFHEKHHSHRGY; ARG22-Histatin 5; P155
EINECS	Contact for details

Quality Control

Our Histatin-5 is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters. While not intended for human therapeutic use as supplied, our quality system is designed to support customers requiring material for GLP or pre-clinical studies.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This peptide is hygroscopic (moisture-sensitive) and easily oxidized; therefore, it is recommended to store under an inert atmosphere after opening and allow the vial to equilibrate to room temperature before use to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.