Description

4-Bromo-2,6-Difluorophenol is a halogenated fluorophenol derivative that serves as a versatile and critical building block in advanced organic synthesis. This compound is valued for its unique substitution pattern, which allows for selective functionalization and the introduction of both bromine and fluorine atoms into target molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery for fluorinated compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the difluorophenol moiety is required.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of monomers and polymers for specialty materials, such as liquid crystals and high-performance polymers.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Fluorine Chemistry Studies: A valuable reagent for studying structure-activity relationships (SAR) and the effects of fluorine substitution in organic molecules.

Basic Information

Item	Detail
Product Name	4-Bromo-2,6-Difluorophenol
CAS No.	104197-13-9
Molecular Formula	C6H3BrF2O
Molecular Weight	208.99 g/mol
Synonyms	2,6-Difluoro-4-bromophenol; 4-Bromo-2,6-difluorophenol; Phenol, 4-bromo-2,6-difluoro-; 4-Brom-2,6-difluor-phenol; 4-Bromo-2,6-difluoro phenol
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,6-Difluorophenol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for production and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.