Description

n-Formyl-Met-Leu-Phe-Lys Acetate Salt is a synthetic formylated tetrapeptide derivative, widely recognized as a potent and specific chemoattractant for neutrophils. This compound is a critical research tool for studying the formyl peptide receptor (FPR) signaling pathway, which plays a central role in innate immune responses and inflammatory processes. It is essential for researchers and developers in immunology, pharmacology, and drug discovery who require a high-purity, reliable reference standard for in vitro and in vivo studies.

Application

• Immunology Research: Used as a standard chemoattractant to study neutrophil migration, activation, and degranulation in models of inflammation.
• Drug Discovery & Screening: Serves as a key agonist for high-throughput screening (HTS) assays to identify novel FPR antagonists or modulators for anti-inflammatory therapeutics.
• Signal Transduction Studies: Employed to investigate intracellular calcium flux, MAPK/ERK pathways, and other downstream effects of FPR activation.
• Inflammation Modeling: Used in experimental models to induce controlled neutrophil recruitment for evaluating potential anti-inflammatory compounds.
• Biochemical Reagent: Functions as a critical component in cell-based assays and diagnostic test development related to immune function.
• Academic & Pharmaceutical R&D: Provides a fundamental research chemical for universities, contract research organizations (CROs), and biopharma companies.

Basic Information

Product Name	n-Formyl-Met-Leu-Phe-Lys Acetate Salt
CAS No.	104180-18-9
Molecular Formula	C33H55N7O8 • xC2H4O2
Molecular Weight	677.84 g/mol (Free base)
Synonyms	fMLFK Acetate; N-Formylmethionyl-leucyl-phenylalanyl-lysine Acetate; Formyl-Met-Leu-Phe-Lys; Chemotactic Peptide fMLFK; fMLP-K Acetate; Formyl Peptide fMLFK; N-Formyl-MLFK; For-Met-Leu-Phe-Lys-OH Acetate
EINECS	Contact for details

Quality Control

Our n-Formyl-Met-Leu-Phe-Lys Acetate Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and nuclear magnetic resonance (NMR) spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	1.0 - 3.0 eq
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.