Description

Z-D-Pro-Osu CAS NO 104055-24-5 is a protected amino acid derivative, specifically the N-benzyloxycarbonyl (Z) derivative of D-proline activated with an N-hydroxysuccinimide (Osu) ester. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the efficient and racemization-free incorporation of the D-proline residue into peptide chains. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing novel peptide-based therapeutics, diagnostics, and research tools that require precise stereochemistry and high coupling efficiency.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the controlled introduction of D-proline into custom peptide sequences.
• Pharmaceutical Intermediates: Used in the research and development of peptide drugs, including hormone analogs, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation: Facilitates the site-specific labeling or modification of proteins and other biomolecules with peptide tags.
• Chemical Biology Probes: Synthesis of modified peptides used as tools to study enzyme function, protein-protein interactions, and cellular pathways.
• Combinatorial Chemistry Libraries: Building block for creating diverse peptide libraries for high-throughput screening in drug discovery.
• Academic & Industrial Research: Fundamental reagent for synthetic organic chemistry and peptide science research projects.

Basic Information

Product Name	Z-D-Pro-Osu
CAS No.	104055-24-5
Molecular Formula	C₁₇H₁₈N₂O₆
Molecular Weight	346.34 g/mol
Synonyms	N-Cbz-D-proline N-hydroxysuccinimide ester; Nα-Benzyloxycarbonyl-D-proline N-succinimidyl ester; Z-D-Pro-OSu; Cbz-D-Pro-OSu; (R)-1-((Benzyloxy)carbonyl)pyrrolidine-2-carboxylic acid 2,5-dioxopyrrolidin-1-yl ester; N-Carbobenzoxy-D-proline succinimidyl ester; D-Proline, N-[(phenylmethoxy)carbonyl]-, 1,2,5-pyrrolidinetrione 1-ester; N-[(Benzyloxy)carbonyl]-D-proline N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our Z-D-Pro-Osu is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.