Description

1,8-Naphthyridine-3-Carboxylic Acid, 7-(3-Amino-1-Pyrrolidinyl)-1-(2,4-Difluorophenyl)-6-Fluoro-1,4-Dihydro-4-Oxo-, Hydrochloride (1:1) is a high-purity, advanced pharmaceutical intermediate belonging to the fluoroquinolone antibiotic class. This compound is critical for the research, development, and synthesis of next-generation antibacterial agents, offering a sophisticated chemical scaffold for medicinal chemistry. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers serving the global life sciences sector.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A key building block in the production of novel fluoroquinolone antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new antibacterial candidates.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions.
• Process Chemistry: Employed in route scouting, optimization, and scale-up processes for API manufacturing.
• Biochemical Research: Utilized in studies investigating bacterial DNA gyrase and topoisomerase IV inhibition mechanisms.

Basic Information

Product Name	1,8-Naphthyridine-3-Carboxylic Acid, 7-(3-Amino-1-Pyrrolidinyl)-1-(2,4-Difluorophenyl)-6-Fluoro-1,4-Dihydro-4-Oxo-, Hydrochloride (1:1)
CAS No.	104051-69-6
Molecular Formula	C20H18F3N4O3·HCl
Molecular Weight	464.84 g/mol
Synonyms	Trovafloxacin Impurity; Trovafloxacin Related Compound; 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Impurity; 7-(3-Aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid Hydrochloride; Alatrofloxacin Impurity; CP-99,219-27
EINECS	Contact for details

Quality Control

Our 1,8-Naphthyridine-3-Carboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, NMR) to ensure it meets the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.