Description

2-Hydroxy-4-(Trifluoromethyl)Pyrimidine is a versatile pyrimidine derivative distinguished by its trifluoromethyl and hydroxyl functional groups, offering unique reactivity and physicochemical properties. This compound is a critical pharmaceutical intermediate and building block for advanced organic synthesis, valued for its ability to modulate the biological activity and metabolic stability of target molecules. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Serves as a precursor for novel herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced efficacy and environmental persistence.
• Ligand & Catalyst Development: Used in the design of novel ligands for transition metal catalysis and organocatalysts due to its electron-withdrawing and coordinating properties.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs).
• Fluorine Chemistry Building Block: Essential for introducing the trifluoromethyl moiety into complex molecules, a common strategy in medicinal chemistry to improve lipophilicity and metabolic stability.

Basic Information

Product Name	2-Hydroxy-4-(Trifluoromethyl)Pyrimidine
CAS No.	104048-92-2
Molecular Formula	C5H3F3N2O
Molecular Weight	164.09 g/mol
Synonyms	4-(Trifluoromethyl)-2-pyrimidinol; 4-(Trifluoromethyl)pyrimidin-2-ol; 2-Pyrimidinol, 4-(trifluoromethyl)-; 2-Hydroxy-4-trifluoromethylpyrimidine; 2(1H)-Pyrimidinone, 4-(trifluoromethyl)-; 4-Trifluoromethyl-2-hydroxypyrimidine; 4-Trifluoromethylpyrimidin-2-ol
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-4-(Trifluoromethyl)Pyrimidine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.