Description

Tyrosyl-Cyclo(Lysyl-Glycyl-Phenylalanyl-Psi(Thiomethylene)Leucine) is a specialized cyclic peptide derivative featuring a unique thiomethylene pseudopeptide bond, which enhances its metabolic stability and binding affinity. This compound is of significant interest for advanced research in peptide-based drug discovery and biochemical pathway modulation. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on developing novel enzyme inhibitors, receptor ligands, and diagnostic probes.

Application

• Pharmaceutical Research: Serves as a key intermediate or lead compound in the development of novel therapeutics targeting proteases and other enzymatic pathways.
• Biochemical Tool: Used as a selective enzyme inhibitor or receptor modulator in mechanistic studies and high-throughput screening assays.
• Peptide Engineering: Acts as a model compound for studying the effects of pseudopeptide bonds (psi-bonds) and cyclization on peptide stability, bioavailability, and activity.
• Diagnostic Development: Potential use in the design of labeled probes for imaging or detecting specific biological targets.
• Academic & Contract Research: Employed in universities and CROs for fundamental research in medicinal chemistry and peptide science.

Basic Information

Product Name	Tyrosyl-Cyclo(Lysyl-Glycyl-Phenylalanyl-Psi(Thiomethylene)Leucine)
CAS No.	103881-76-1
Molecular Formula	C41H58N8O8S
Molecular Weight	823.02 g/mol
Synonyms	Cyclo(Tyr-Lys-Gly-Phe-ψ[CH2S]Leu); Tyr-c[Lys-Gly-Phe-ψ(CS-N)Leu]; Cyclic Peptide Inhibitor 103881-76-1; Thiomethylene Pseudopeptide; Psi-Thiomethylene Leu-containing Cyclopeptide; TFA salt of Tyrosyl-Cyclo(Lysyl-Glycyl-Phenylalanyl-Psi(Thiomethylene)Leucine) (common salt form); [Tyrosine1, Lysine2, Glycine3, Phenylalanine4, ψ(Thiomethylene)Leucine5]-cyclopeptide
EINECS	Contact for details

Quality Control

Our Tyrosyl-Cyclo(Lysyl-Glycyl-Phenylalanyl-Psi(Thiomethylene)Leucine) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure structural integrity. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, supporting research requiring high-purity, well-characterized biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.