Description

Gastric Inhibitory Polypeptide (1-39) CAS NO 103842-36-0 is a synthetic 39-amino acid peptide fragment corresponding to the N-terminal sequence of the full-length human Gastric Inhibitory Polypeptide (GIP) hormone. This high-purity peptide is a critical research tool for investigating the role of GIP in glucose-dependent insulin secretion, energy metabolism, and its potential links to metabolic disorders. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on endocrinology, diabetes research, and the development of novel therapeutics.

Application

• Biomedical Research: Fundamental studies on GIP receptor (GIPR) binding, activation, and downstream signaling pathways.
• Drug Discovery & Development: Used as a reference standard, competitor, or tool compound in high-throughput screening (HTS) assays for identifying GIPR agonists or antagonists.
• Metabolic Disease Studies: Investigating the incretin effect, β-cell function, and the pathophysiology of type 2 diabetes and obesity.
• Analytical Standard: Serves as a primary standard for the quantification and validation of GIP levels in biological samples via ELISA, RIA, or LC-MS/MS methods.
• Peptide Chemistry & Conjugation: Acts as a starting material or core structure for the synthesis of labeled derivatives (e.g., fluorescent, biotinylated) or novel peptide analogs.
• In Vitro & Ex Vivo Models: Application in cell-based assays (e.g., insulinoma cell lines) and isolated tissue/organ preparations to study physiological responses.

Basic Information

Product Name	Gastric Inhibitory Polypeptide (1-39)
CAS No.	103842-36-0
Molecular Formula	C187H295N55O57
Molecular Weight	4233.7 g/mol (monoisotopic)
Synonyms	GIP (1-39); Glucose-dependent Insulinotropic Polypeptide (1-39); Human Gastric Inhibitory Polypeptide (1-39); hGIP(1-39); Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln; GIP fragment 1-39, human; Gastric inhibitory peptide (1-39)
EINECS	Contact for details

Quality Control

Our Gastric Inhibitory Polypeptide (1-39) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC for purity, MS for molecular weight confirmation, and amino acid analysis. We adhere to high standards suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by Mass Spectrometry
Purity (HPLC)	≥ 95% (Area Percent)
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.