Description

Tyrosyl-Alanyl-Glycyl-Phenylalanyl-Psi(Thiomethylene)Leucine is a synthetic peptide derivative featuring a thiomethylene pseudopeptide bond, which enhances its metabolic stability and bioavailability. This modification makes it a valuable tool compound for biochemical research and pharmaceutical development, particularly in studying protease inhibition and peptide-based drug design. It is essential for researchers and manufacturers in the fields of medicinal chemistry, enzymology, and advanced peptide therapeutics.

Application

• Protease Inhibition Studies: Used as a stable, non-hydrolyzable substrate analog to investigate enzyme mechanisms and kinetics.
• Medicinal Chemistry Research: Serves as a key intermediate or reference standard in the development of novel peptide-based pharmaceuticals.
• Biochemical Assay Development: Employed in the design and validation of high-throughput screening assays for drug discovery.
• Academic & Institutional Research: A critical reagent for universities and R&D institutes focusing on peptide science and enzymology.
• Pharmaceutical Reference Standard: Used for quality control and analytical method development in GMP environments.

Basic Information

Product Name	Tyrosyl-Alanyl-Glycyl-Phenylalanyl-Psi(Thiomethylene)Leucine
CAS No.	103834-43-1
Molecular Formula	C36H49N7O8S
Molecular Weight	739.89 g/mol
Synonyms	Tyr-Ala-Gly-Phe-ψ[CH2S]-Leu; YAGF-ψ[CH2S]-L; Thioamide Peptide Inhibitor; Pseudopeptide YAGFL; CAS 103834-43-1; Tyrosine-Alanine-Glycine-Phenylalanine-Psi(Thiomethylene)Leucine; Protease Inhibitor Peptide Analog
EINECS	Contact for details

Quality Control

Our Tyrosyl-Alanyl-Glycyl-Phenylalanyl-Psi(Thiomethylene)Leucine is manufactured under strict quality management systems. Each batch is characterized and tested to ensure identity, purity, and consistency, meeting the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing results from HPLC, MS, and NMR analyses is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.