Description

H-D-His(Bzl)-Oh CAS NO 103772-40-3 is a protected derivative of the amino acid histidine, specifically the benzyl-protected form of D-histidine. This compound is a critical chiral building block in the synthesis of complex peptides and pharmaceutical intermediates, offering precise stereochemical control. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced chemical synthesis sectors who require high-purity, specialty amino acids for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a protected histidine residue, preventing unwanted side reactions.
• Bioconjugation & Labeling: Serves as a precursor for creating modified peptides used in diagnostic assays, imaging probes, and antibody-drug conjugates (ADCs).
• Biochemical Research: Employed in enzymatic studies, receptor-ligand interaction research, and as a standard in analytical method development.
• Catalyst & Ligand Preparation: Utilized in the development of chiral catalysts and ligands for asymmetric synthesis in fine chemical manufacturing.

Basic Information

Product Name	H-D-His(Bzl)-Oh
CAS No.	103772-40-3
Molecular Formula	C13H17N3O2
Molecular Weight	247.29 g/mol
Synonyms	D-Histidine, N(pi)-benzyl-; (R)-2-Amino-3-(1-benzyl-1H-imidazol-4-yl)propanoic acid; D-N(pi)-Benzylhistidine; H-D-His(Bzl)-OH; D-His(Bzl)-OH; Boc-D-His(Bzl)-OH precursor; Fmoc-D-His(Bzl)-OH precursor; D-1-Benzylhistidine
EINECS	Contact for details

Quality Control

Our H-D-His(Bzl)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with your research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.