Description

Dynorphin A Amide (1-9), Cys(2)-Cys(5)-Mearg(7)-Leu(8)- is a synthetic, biologically active peptide fragment derived from the endogenous opioid peptide Dynorphin A. This compound is of significant value for neuroscience and opioid receptor research, serving as a critical tool for studying κ-opioid receptor (KOR) signaling pathways and pain modulation mechanisms. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in neuropharmacology and analgesic drug discovery.

Application

• Neuroscience Research: As a selective ligand for investigating the physiological and pathological roles of κ-opioid receptors (KOR) in the central nervous system.
• Pharmacological Studies: Used in in vitro and in vivo assays to study pain perception, stress responses, and reward pathways mediated by the dynorphin/KOR system.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool in high-throughput screening (HTS) campaigns for novel analgesic and neuropsychiatric therapeutics.
• Biochemical Assays: Employed in receptor binding studies, functional activity tests (e.g., cAMP inhibition, GTPγS binding), and signal transduction research.
• Academic & Clinical Research: Fundamental for exploring the link between the dynorphin system and conditions such as chronic pain, addiction, depression, and neurodegenerative diseases.

Basic Information

Product Name	Dynorphin A Amide (1-9), Cys(2)-Cys(5)-Mearg(7)-Leu(8)-
CAS No.	103614-06-8
Molecular Formula	C48H75N15O11S2
Molecular Weight	1090.33 g/mol
Synonyms	Dynorphin A (1-9) amide; [Cys2, Cys5, MeArg7, Leu8]-Dynorphin A (1-9) amide; [Cys2, Cys5, NG-Methylarginine7, Leu8]-Dynorphin A (1-9) amide; Dynorphin A (1-9)NH2 analog; κ-opioid receptor peptide ligand; Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-NH2 (cyclic disulfide bridge Cys2-Cys5, NG-methyl-Arg7, Leu8)
EINECS	Contact for details

Quality Control

Our Dynorphin A Amide (1-9) analog is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. All products undergo rigorous quality testing, including HPLC for purity analysis and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, content, and analytical results are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.