Description

Oxyntomodulin, Nle(27)- is a synthetic analog of the naturally occurring peptide hormone oxyntomodulin, designed for enhanced stability and research utility. This compound is of significant interest for its role in studying metabolic regulation, particularly appetite control and glucose homeostasis. It is primarily utilized by pharmaceutical researchers, biotechnology companies, and academic institutions engaged in endocrinology and metabolic disease research.

Application

• Pharmacological Research: Used as a key reference standard and active agent in studies investigating the mechanisms of GLP-1 and glucagon receptor dual agonism.
• Metabolic Disease Studies: Critical for in vitro and in vivo research targeting obesity, type 2 diabetes, and related metabolic syndromes.
• Biomarker Development: Serves as a calibrant in the development of immunoassays (e.g., ELISA) for detecting oxyntomodulin-related activity.
• Drug Discovery & Pre-clinical Testing: Employed in high-throughput screening and efficacy testing for next-generation anti-diabetic and weight-management therapeutics.
• Academic & Institutional Research: Supports fundamental research in gastrointestinal endocrinology and hormone signaling pathways.

Basic Information

Product Name	Oxyntomodulin, Nle(27)-
CAS No.	103598-48-7
Molecular Formula	C215H337N61O63S2
Molecular Weight	~4760.5 g/mol
Synonyms	Nle27-Oxyntomodulin; Norleucine27-Oxyntomodulin; OXM (1-37), Nle27-; Oxyntomodulin (Nle(27)); Glucagon-37, Nle(27)-; [Nle27]Oxyntomodulin; [Norleucine27]Oxyntomodulin
EINECS	Contact for details

Quality Control

Our Oxyntomodulin, Nle(27)- is manufactured under strict quality systems suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing purity, peptide content, and related substance profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.