Description

Argipressin, β-Mercapto(Beta,Beta)-Cyclopentamethylenepropionic Acid(1)-Ile(2,4)- is a synthetic analogue of the neurohypophysial hormone vasopressin, specifically engineered for enhanced receptor binding affinity and metabolic stability. This compound is critical for research and development in advanced pharmaceutical applications, particularly where precise modulation of antidiuretic and vasopressor activity is required. It serves as a key intermediate and reference standard for scientists in the fields of endocrinology, peptide chemistry, and drug discovery.

Application

• Pharmaceutical Research & Development: Primary use as a high-purity reference standard and active pharmaceutical ingredient (API) intermediate in the synthesis of novel vasopressin receptor agonists and antagonists.
• Biochemical Assays: Utilized in in vitro and in vivo studies to investigate the V1a and V2 receptor pathways, aiding in the understanding of water balance, blood pressure regulation, and coagulation.
• Peptide Chemistry Studies: Serves as a model compound for studying structure-activity relationships (SAR) due to its modified cyclic structure with β-mercapto and cyclopentamethylenepropionic acid groups.
• Diagnostic Agent Development: Potential use in the development of diagnostic tools and imaging agents targeting vasopressin receptors in various physiological and pathological states.

Basic Information

Product Name	Argipressin, β-Mercapto(Beta,Beta)-Cyclopentamethylenepropionic Acid(1)-Ile(2,4)-
CAS No.	103529-95-9
Molecular Formula	C46H65N13O12S2
Molecular Weight	1008.2 g/mol
Synonyms	[1-(β-Mercapto-β,β-cyclopentamethylenepropionic acid), 2-(O-methyl-L-tyrosine), 4-L-isoleucine, 8-L-arginine]vasopressin; [1-(Mpa1), 2-(Tyr(Me)2), 4-Ile4, 8-Arg8]VP; d(CH2)5[Tyr(Me)2, Ile4, Arg8]vasopressin; β-Mercapto-Beta,β-Cyclopentamethylene Propionyl1-O-Methyl-Tyrosine2-Isoleucine4-Arginine8-Vasopressin; Manning Compound; V1a Vasopressin Receptor Antagonist; SR 49059 (related research code).
EINECS	Contact for details

Quality Control

Our Argipressin, β-Mercapto(Beta,Beta)-Cyclopentamethylenepropionic Acid(1)-Ile(2,4)- is manufactured under strict quality systems suitable for research and development. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at a controlled room temperature between 15°C and 25°C (59°F and 77°F). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.