Description

Lys-Lys-(Hyp3,β-(2-Thienyl)-Ala5,8,D-Phe7)-Bradykinin is a synthetic, modified peptide analog of the endogenous vasoactive peptide bradykinin. This compound matters for advanced research into the bradykinin B2 receptor system, offering a tool with enhanced stability and specific binding properties for mechanistic studies. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cardiovascular pharmacology, inflammation, pain pathways, and novel therapeutic target validation.

Application

• Pharmacological Research: A key tool for studying the structure-activity relationships (SAR) of bradykinin B2 receptor ligands.
• Receptor Binding Assays: Used in competitive binding studies to characterize receptor affinity and selectivity due to its modified structure.
• Signal Transduction Studies: Investigates intracellular pathways activated by the kinin system in various cell types.
• Drug Discovery Programs: Serves as a reference compound or a lead structure in the development of novel anti-inflammatory or analgesic agents.
• Biochemical Standard: Employed as a high-purity standard in analytical method development (e.g., HPLC, LC-MS) for peptide quantification.
• Academic & Institutional Research: Supports fundamental research in physiology and pathophysiology related to blood pressure regulation and vascular permeability.

Basic Information

Product Name	Lys-Lys-(Hyp3,β-(2-Thienyl)-Ala5,8,D-Phe7)-Bradykinin
CAS No.	103412-40-4
Molecular Formula	C68H94N18O14S2
Molecular Weight	1451.7 g/mol
Synonyms	Lys-Lys-[Hyp³,β-(2-Thienyl)-Ala⁵,⁸,D-Phe⁷]-Bradykinin; [Hyp³,β-(2-Thienyl)-Ala⁵,⁸,D-Phe⁷]-Bradykinin, Lys-Lys-; Bradykinin, Lys-Lys-[Hyp³,β-(2-thienyl)Ala⁵,⁸,D-Phe⁷]-; Lys-Lys-(Hyp³,β-(2-Thienyl)Ala⁵,⁸,D-Phe⁷)-Bradykinin; Modified Bradykinin Analog; B2 Receptor Ligand Analog; [Lys-Lys⁰,Hyp³,β-(2-Thienyl)-Ala⁵,⁸,D-Phe⁷]-BK
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity (by HPLC), peptide content, and identity confirmation. We adhere to GMP principles in our manufacturing processes to ensure batch-to-batch consistency for research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.