Description

Boc-D-His(Dnp)-Oh is a protected, non-natural amino acid derivative of significant importance in advanced peptide synthesis. This compound, with CAS No. 103343-26-6, is specifically engineered to provide orthogonal protection for the histidine side chain, enabling precise and complex peptide assembly. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical building block for the controlled incorporation of D-histidine into peptide chains, especially where the imidazole side chain requires specific protection.
• Pharmaceutical Research & Development: Used in the synthesis of peptide drug candidates, including hormone analogs, enzyme inhibitors, and targeted delivery vectors.
• Bioconjugation and Probe Development: Serves as a precursor for creating labeled peptides for diagnostic assays, imaging probes, and affinity purification tags.
• Structure-Activity Relationship (SAR) Studies: Enables the exploration of peptide bioactivity by systematically modifying the histidine residue with D-configuration and protected side chains.
• Custom Peptide Service Providers: A key raw material for CROs and CDMOs offering bespoke peptide synthesis services to academic and industrial clients.
• Academic Research: Fundamental research in biochemistry, medicinal chemistry, and chemical biology for studying peptide folding, stability, and receptor interactions.

Basic Information

Product Name	Boc-D-His(Dnp)-Oh
CAS No.	103343-26-6
Molecular Formula	C₁₇H₂₀N₆O₇
Molecular Weight	420.38 g/mol
Synonyms	Boc-D-histidine(Dnp)-OH; (2R)-2-[(tert-Butoxycarbonyl)amino]-3-[1-(2,4-dinitrophenyl)-1H-imidazol-4-yl]propanoic acid; N-α-(tert-Butoxycarbonyl)-N-π-(2,4-dinitrophenyl)-D-histidine; Boc-D-His(Dnp)-OH; Boc-D-His(Dnp); D-Boc-His(Dnp)-OH; tert-Butyloxycarbonyl-D-histidine(2,4-dinitrophenyl)-OH
EINECS	Contact for details

Quality Control

Our Boc-D-His(Dnp)-Oh is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm D-configuration, and spectroscopic identification. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and strictly light-sensitive; therefore, it must be handled under inert atmosphere when appropriate and protected from all light exposure during long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.