Description

Fmoc-Lys(Z)-Cl CAS NO 103321-56-8 is a protected amino acid derivative, specifically an N-α-Fmoc and N-ε-Cbz protected lysine side-chain activated as an acid chloride. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and efficient incorporation of lysine residues into complex peptide sequences. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the stepwise assembly of peptides, particularly for introducing lysine with orthogonal side-chain protection.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs, including hormones, antimicrobial peptides, and targeted therapeutics.
• Bioconjugation and Labeling: The reactive acid chloride group facilitates coupling reactions for attaching peptides to other molecules, surfaces, or reporter tags.
• Combinatorial Chemistry: Employed in libraries for drug discovery to create diverse arrays of compounds containing lysine motifs.
• Biochemical Research: Serves as a precise tool for studying protein-protein interactions, enzyme substrates, and signal transduction pathways.
• Material Science: Used in the synthesis of peptide-polymer conjugates and bio-functionalized materials.

Basic Information

Item	Detail
Product Name	Fmoc-Lys(Z)-Cl
CAS No.	103321-56-8
Molecular Formula	C30H31ClN2O5
Molecular Weight	535.03 g/mol
Synonyms	Fmoc-Lys(Z)-Chloride; Nα-Fmoc-Nε-Cbz-L-lysine chloride; Nα-(9-Fluorenylmethoxycarbonyl)-Nε-(benzyloxycarbonyl)-L-lysine chloride; Fmoc-Lys(Cbz)-Cl; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((benzyloxy)carbonyl)amino)hexanoyl chloride; Fmoc-Lys(Boc)-Cl (common mis-association); Fmoc-Lys(Alloc)-Cl (related compound); Fmoc-L-Lys(Z)-Cl
EINECS	Contact for details

Quality Control

Our Fmoc-Lys(Z)-Cl is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and cGMP-guided production. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent in-house specifications aligned with industry best practices for peptide synthesis reagents.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere or in a desiccator to prevent decomposition. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.