Description

Fmoc-Cys(Bzl)-Cl CAS NO 103321-55-7 is a protected amino acid derivative, specifically an Fmoc-protected cysteine benzyl chloride, designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the controlled introduction of cysteine residues, enabling the formation of disulfide bridges essential for the tertiary structure and biological activity of complex peptides and proteins. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, biochemical probes, and high-value synthetic targets.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key reagent for the sequential coupling of cysteine in Fmoc-based peptide assembly.
• Therapeutic Peptide Development: For constructing peptides with defined disulfide bond patterns critical for stability and bioactivity in drug candidates.
• Bioconjugation and Protein Engineering: Enables site-specific modification of peptides and proteins via the reactive thiol group after deprotection.
• Chemical Biology Research: Used in synthesizing peptide-based probes, enzyme inhibitors, and tools for studying protein-protein interactions.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a precursor for constructing specialized linkers that connect cytotoxic payloads to antibodies.
• Material Science: For creating peptide-based biomaterials and self-assembling nanostructures where cysteine mediates cross-linking.

Basic Information

Product Name	Fmoc-Cys(Bzl)-Cl
CAS No.	103321-55-7
Molecular Formula	C25H22ClNO4S
Molecular Weight	467.96 g/mol
Synonyms	Fmoc-Cys(Bzl)-Cl; Fmoc-S-benzyl-L-cysteine chloride; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-benzyl-L-cysteine chloride; Fmoc-Cysteine(Bzl)-OH chloride; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(benzylsulfanyl)propanoic acid chloride; Fmoc-Cys(Bzl)-O-Cl; Fmoc-L-Cysteine(S-benzyl) chloride; N-Fmoc-S-benzylcysteine chloride
EINECS	Contact for details

Quality Control

Our Fmoc-Cys(Bzl)-Cl is manufactured under strict quality control protocols to ensure high chemical purity and consistency, meeting the stringent requirements of peptide synthesis. Each batch is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.