Description

Fmoc-L-Methionyl Chloride CAS NO 103321-54-6 is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the efficient and selective incorporation of methionine into peptide chains under standard Fmoc-chemistry protocols. It is an essential reagent for pharmaceutical R&D, biotechnology, and academic laboratories focused on developing novel therapeutic peptides, peptide hormones, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the sequential coupling of methionine residues in Fmoc-based peptide assembly.
• Pharmaceutical Research: Used in the development and production of therapeutic peptides targeting metabolic disorders, oncology, and infectious diseases.
• Bioconjugation & Labeling: Facilitates the site-specific introduction of methionine or its derivatives for creating peptide-protein conjugates or labeled compounds.
• Combinatorial Chemistry: Employed in library synthesis for high-throughput screening of bioactive peptide sequences.
• Academic & Biochemical Research: Essential for studying protein structure-function relationships, enzyme substrates, and receptor ligands.
• Custom Peptide Service Providers: A fundamental raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Fmoc-L-Methionyl Chloride
CAS No.	103321-54-6
Molecular Formula	C21H22ClNO4S
Molecular Weight	419.92 g/mol
Synonyms	Fmoc-Met-Cl; Fmoc-Methionine Chloride; N-(9-Fluorenylmethoxycarbonyl)-L-methionyl chloride; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-(methylsulfanyl)butanoyl chloride; N-Fmoc-L-methionyl chloride; Fmoc-L-methionine acid chloride; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-methionyl chloride
EINECS	Contact for details

Quality Control

Our Fmoc-L-Methionyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in dichloromethane, DMF, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.