Description

Fmoc-Ile-Cl is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled and efficient incorporation of isoleucine into complex peptide chains while preventing unwanted side reactions. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in the production of therapeutic peptides, biochemical probes, and novel drug candidates. Its reliable performance is fundamental to advancing projects in medicinal chemistry and biotechnology.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid chloride, it is a key reagent for the sequential coupling of isoleucine residues in automated and manual peptide synthesis.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Bioconjugation: Facilitates the site-specific labeling or modification of peptides and proteins for diagnostic or research purposes.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive peptide leads.
• Academic & Industrial Research: A fundamental tool for studying protein structure-function relationships, enzyme substrates, and receptor ligands.
• Custom Peptide Service Providers: A staple raw material for CROs and CDMOs offering bespoke peptide manufacturing services.

Basic Information

Product Name	Fmoc-Ile-Cl
CAS No.	103321-51-3
Molecular Formula	C21H22ClNO3
Molecular Weight	371.86 g/mol
Synonyms	Fmoc-Isoleucine Chloride; N-(9-Fluorenylmethoxycarbonyl)-L-isoleucine Chloride; (2S,3S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylpentanoyl Chloride; Fmoc-L-Ile-Cl; Fmoc-Ile-OCl; Nα-Fmoc-L-isoleucine acid chloride; 9-Fluorenylmethyloxycarbonylisoleucine chloride; N-Fmoc-isoleucine chloride
EINECS	Contact for details

Quality Control

Every batch of Fmoc-Ile-Cl is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for sensitive peptide synthesis. Our quality commitment includes providing a detailed Certificate of Analysis (COA) with each shipment, which reports key parameters such as purity (by HPLC), chiral purity, and moisture content. We adhere to cGMP guidelines where applicable to support our customers' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DCM, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.