Description

(3,5-Diiodo-Tyr1,D-Ala2)-Met-Enkephalin Amide Acetate Salt is a chemically modified, iodinated analog of the endogenous opioid peptide Met-enkephalin. This compound is of significant value in neuroscience and pharmaceutical research as a potent and selective ligand for studying delta opioid receptor (DOR) activity and signal transduction pathways. It is primarily utilized by research institutions and pharmaceutical developers focused on neuropharmacology, pain management, and the development of novel central nervous system (CNS) therapeutics.

Application

• Neuroscience Research: Used as a high-affinity, selective agonist for in vitro and in vivo studies of delta opioid receptor (DOR) function and distribution.
• Pharmacological Assay Development: Serves as a critical reference standard and tool compound in receptor binding assays, cAMP inhibition tests, and GTPγS binding assays.
• Pain Mechanism Studies: Employed in preclinical research to investigate the role of the DOR in analgesia, tolerance, and dependence, aiding in the understanding of pain pathways.
• Drug Discovery & Development: Acts as a key intermediate or pharmacological probe in the design and screening of new analgesic and neuroprotective drug candidates targeting opioid receptors.
• Biochemical Characterization: Utilized in structure-activity relationship (SAR) studies to elucidate the impact of halogenation and D-amino acid substitution on peptide stability and receptor interaction.
• Academic & Institutional Research: Supports fundamental research in universities and government labs exploring neuropeptides, G-protein coupled receptors (GPCRs), and their physiological roles.

Basic Information

Product Name	(3,5-Diiodo-Tyr1,D-Ala2)-Met-Enkephalin Amide Acetate Salt
CAS No.	103226-15-9
Molecular Formula	C33H43I2N7O8S • xC2H4O2
Molecular Weight	911.61 g/mol (Free base, without acetate)
Synonyms	DADLE (Iodinated); [D-Ala2, 3,5-Diiodo-Tyr1]-Met-Enkephalinamide Acetate; (3,5-Diiodo-Tyr1, D-Ala2)-Met-Enkephalin Amide; Tyr-D-Ala-Gly-Phe-Met-NH2 (3',5'-Diiodo-Tyr1, D-Ala2); Delta Opioid Receptor Agonist (iodinated); DADLE analog; 103226-15-9; Iodinated Enkephalin Amide
EINECS	Contact for details

Quality Control

Our (3,5-Diiodo-Tyr1,D-Ala2)-Met-Enkephalin Amide Acetate Salt is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency suitable for critical research applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, MS, and NMR. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and content. Our quality system supports compliance with relevant standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with molecular structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC / IC)	1.0 - 2.0 equivalents
Peptide Content	≥ 80% (by weight)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.