Description

Fmoc-S-Trityl-L-Cysteine CAS NO 103213-32-7 is a high-purity, orthogonally protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is specifically engineered to provide selective deprotection, where the Fmoc group is removed under mild basic conditions while the S-trityl moiety remains intact, allowing for precise cysteine incorporation. It is a critical building block for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research who require reliable, high-quality reagents for synthesizing complex peptides and bioconjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tBu strategy, enabling the controlled introduction of cysteine residues.
• Pharmaceutical Intermediate: Used in the research and production of therapeutic peptides, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation and Protein Engineering: Serves as a precursor for introducing thiol groups into peptides for site-specific labeling, PEGylation, or cross-linking.
• Chemical Biology Research: A vital tool for studying protein folding, disulfide bond formation, and structure-activity relationships (SAR).
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive peptide leads.
• Diagnostic Reagent Development: Used in the synthesis of peptide-based probes and assay components.

Basic Information

Item	Details
Product Name	Fmoc-S-Trityl-L-Cysteine
CAS No.	103213-32-7
Molecular Formula	C43H35NO4S
Molecular Weight	661.81 g/mol
Synonyms	Fmoc-Cys(Trt)-OH; N-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-cysteine; Fmoc-L-Cysteine(S-trityl); (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-(tritylsulfanyl)propanoic acid; N-α-Fmoc-S-trityl-L-cysteine; Fmoc-Cys(Trt)-OH; Fmoc-Cys(Trt); Fmoc-S-Trt-L-Cys-OH
EINECS	Contact for details

Quality Control

Our Fmoc-S-Trityl-L-Cysteine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and cGMP applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.