Description

Fmoc-3,5-Diiodo-L-Tyrosine is a protected, non-natural amino acid derivative essential for advanced peptide synthesis. This compound is a critical building block for introducing iodinated tyrosine residues into peptide chains, enabling the creation of novel structures for research and development. It is primarily utilized by pharmaceutical researchers, peptide chemists, and biotechnology companies engaged in drug discovery, radiopharmaceutical development, and the study of protein-protein interactions.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the Fmoc-strategy synthesis of complex peptides containing iodinated tyrosine.
• Radiopharmaceutical Precursor: Serves as a precursor for radioiodination, enabling the development of diagnostic and therapeutic agents for oncology and neurology.
• Bioconjugation & Probe Development: Used to incorporate iodine atoms into peptides for use as molecular probes, tags, or for cross-linking studies in biochemical research.
• Structure-Activity Relationship (SAR) Studies: Facilitates the exploration of peptide bioactivity by systematically modifying the tyrosine residue with halogen atoms.
• Peptidomimetic & Drug Discovery: Enables the design and synthesis of stable peptide analogs and novel drug candidates with enhanced binding properties or metabolic stability.
• Material Science & Surface Functionalization: Can be used to create peptide-based biomaterials or functionalize surfaces with specific, iodinated peptide sequences.

Basic Information

Product Name	Fmoc-3,5-Diiodo-L-Tyrosine
CAS No.	103213-31-6
Molecular Formula	C24H19I2NO5
Molecular Weight	679.22 g/mol
Synonyms	Fmoc-Tyr(3,5-I2)-OH; N-(9-Fluorenylmethoxycarbonyl)-3,5-diiodo-L-tyrosine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(3,5-diiodo-4-hydroxyphenyl)propanoic acid; Fmoc-3,5-diiodotyrosine; Fmoc-L-3,5-Diiodotyrosine; N-Fmoc-3,5-diiodo-L-tyrosine; 3,5-Diiodo-L-tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Fmoc-3,5-Diiodo-L-Tyrosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.