Description

Gly-Phe-Arg Dihydrochloride is a high-purity tripeptide derivative, specifically the dihydrochloride salt of the Glycyl-Phenylalanyl-Arginine sequence. This compound serves as a critical synthetic intermediate and biochemical tool in advanced research and development. It is primarily utilized by pharmaceutical, biotechnology, and life science research organizations for applications in peptide synthesis, enzyme substrate studies, and as a reference standard.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for proteases like thrombin and trypsin, to investigate catalytic mechanisms.
• Peptide Synthesis: An essential raw material for solid-phase and solution-phase peptide synthesis (SPPS) to construct longer peptide chains.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in analytical laboratories.
• Cell Culture & Diagnostics: Potential application in cell signaling studies and as a component in diagnostic assay development.

Basic Information

Product Name	Gly-Phe-Arg Dihydrochloride
CAS No.	103192-42-3
Molecular Formula	C20H31N7O4 • 2HCl
Molecular Weight	522.43 g/mol
Synonyms	Glycyl-L-phenylalanyl-L-arginine dihydrochloride; GFR dihydrochloride; H-Gly-Phe-Arg-OH • 2HCl; L-Arginine, N2-[(phenylacetyl)glycyl]-, dihydrochloride; Peptide GFR 2HCl; N-Glycyl-L-phenylalanyl-L-arginine dihydrochloride; Gly-Phe-Arg-2HCl; Boc-Gly-Phe-Arg(Tos)-OH related compound (if applicable)
EINECS	Contact for details

Quality Control

Our Gly-Phe-Arg Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets stringent specifications for research and pharmaceutical use. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Total)	≥ 99.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.